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Bioreactor design and operation including bacteria, yeast and tissue culture, formulation, bioseparations.
TopicsProf. Conan Fee: 10 lecturesBioseparations and Chromatography • Bioproducts• Review of biological molecule properties (emphasis on proteins)• General bioseparation principles• Process scale protein chromatography• Adsorption isotherms• Bioseparation strategies• Optimisation and scale-upDr. Tim Huber: 10 lecturesBiomimetics and Biomaterials• Introduction to biomimetics• Natural and nature-inspired biomaterials• Lessons from Nature in regenerative medicine• Biomimetic based design and organisation principles• Surface structures in Nature and resulting applications• Case study 1: The Lotus leaf and rose petal effects as examples for super hydrophobic and super hydrophilic surfaces• Bio-based adhesion principles demonstrated by Spider-silk and seaweed glue• Case study 2: Superhero-mimicry; the dry adhesion of Spider-Man its application potentialDr. Gabriel Visnovsky: 16 lecturesAnimal cell culture: uses and applications in industry and biotechnology • Introduction and history. • Design and requirements for setting up an animal cell culture lab. • Security in the lab. • Animal cell culture characteristics and requirements. • Quality control • General techniques and systems for cultivation animal cell culture: static, suspension and microcarriers cell culture.• Factors influencing cell growth: shear stress, bioreactor design and process scale up • Strategies for production process design. Lab, pilot, and large scale: CSTR vs. ALR • Case Study I: Production of Baculovirus in large scale airlift reactors using insect cells• Case Study II: Development, optimisation and scale up of a biotechnological process to produce Oryctes virus.
Students must attend one activity from each section.
and Conan Fee
Ratledge, Colin. , Kristiansen, B;
Cambridge University Press, 2006.
Domestic fee $1,018.00
International fee $4,863.00
For further information see
Chemical and Process Engineering.