Bioprocess Engineering 2

Description

Topics

Prof. Conan Fee: 10 lectures

Bioseparations and Chromatography

• Bioproducts
• Review of biological molecule properties (emphasis on proteins)
• General bioseparation principles
• Process scale protein chromatography
• Adsorption isotherms
• Bioseparation strategies
• Optimisation and scale-up

Dr. Tim Huber: 10 lectures

Biomimetics and Biomaterials

• Introduction to biomimetics
• Natural and nature-inspired biomaterials
• Lessons from Nature in regenerative medicine
• Biomimetic based design and organisation principles
• Surface structures in Nature and resulting applications
• Case study 1: The Lotus leaf and rose petal effects as examples for super hydrophobic and super hydrophilic surfaces
• Bio-based adhesion principles demonstrated by Spider-silk and seaweed glue
• Case study 2: Superhero-mimicry; the dry adhesion of Spider-Man its application potential

Dr. Gabriel Visnovsky:  16 lectures

Animal cell culture: uses and applications in industry and biotechnology
                             
• Introduction and history.
• Design and requirements for setting up an animal cell culture lab.
• Security in the lab.
• Animal cell culture characteristics and requirements.
• Quality control
• General techniques and systems for cultivation animal cell culture: static, suspension and microcarriers cell culture.
• Factors influencing cell growth: shear stress, bioreactor design and process scale up
• Strategies for production process design. Lab, pilot, and large scale: CSTR vs. ALR
• Case Study I: Production of Baculovirus in large scale airlift  reactors using insect cells
• Case Study II: Development, optimisation and scale up of a biotechnological process to produce Oryctes virus.