ENCH482-16S1 (C) Semester One 2016

Bioprocess Engineering 2

15 points, 0.1250 EFTS
22 Feb 2016 - 26 Jun 2016


Bioreactor design and operation including bacteria, yeast and tissue culture, formulation, bioseparations.


Prof. Conan Fee: 10 lectures

Bioseparations and Chromatography

• Bioproducts
• Review of biological molecule properties (emphasis on proteins)
• General bioseparation principles
• Process scale protein chromatography
• Adsorption isotherms
• Bioseparation strategies
• Optimisation and scale-up

Dr. Tim Huber: 10 lectures

Biomimetics and Biomaterials

• Introduction to biomimetics
• Natural and nature-inspired biomaterials
• Lessons from Nature in regenerative medicine
• Biomimetic based design and organisation principles
• Surface structures in Nature and resulting applications
• Case study 1: The Lotus leaf and rose petal effects as examples for super hydrophobic and super hydrophilic surfaces
• Bio-based adhesion principles demonstrated by Spider-silk and seaweed glue
• Case study 2: Superhero-mimicry; the dry adhesion of Spider-Man its application potential

Dr. Gabriel Visnovsky:  16 lectures

Animal cell culture: uses and applications in industry and biotechnology
• Introduction and history.
• Design and requirements for setting up an animal cell culture lab.
• Security in the lab.
• Animal cell culture characteristics and requirements.
• Quality control
• General techniques and systems for cultivation animal cell culture: static, suspension and microcarriers cell culture.
• Factors influencing cell growth: shear stress, bioreactor design and process scale up
• Strategies for production process design. Lab, pilot, and large scale: CSTR vs. ALR
• Case Study I: Production of Baculovirus in large scale airlift  reactors using insect cells
• Case Study II: Development, optimisation and scale up of a biotechnological process to produce Oryctes virus.

Learning Outcomes

University Graduate Attributes

This course will provide students with an opportunity to develop the Graduate Attributes specified below:


Course Coordinator / Lecturer

Gabriel Visnovsky


Tim Huber and Conan Fee


Assessment Due Date Percentage 
Assignment 1 10%
Assignment 2 15%
Assignment 3 18%
Assignment 4 15%
Final Exam 42%


Recommended Reading

Ratledge, Colin. , Kristiansen, B; Basic biotechnology; 3rd ed; Cambridge University Press, 2006.

Indicative Fees

Domestic fee $1,018.00

International fee $4,863.00

* Fees include New Zealand GST and do not include any programme level discount or additional course related expenses.

For further information see Chemical and Process Engineering.

All ENCH482 Occurrences

  • ENCH482-16S1 (C) Semester One 2016