Seminar Series

Development of Novel Delivery Vehicles for Anti-Parasitic Drug Delivery and Transfection

Speaker

Professor Rudi Marquez

Institute

Xian Jiaotong - Liverpool University

Time & Place

Wed, 08 Feb 2017 12:00:00 NZDT in Rutherford Room 531

All are welcome

Abstract

Selective drug delivery in parasitic and bacterial infections is a cornerstone of medicinal chemistry. There have been entire drug research programmes that have been shut down due to toxicity issues that have arisen from unselective targeting and drug delivery. However, drug treatment has a number of associated problems, including the development of drug resistant parasites, poor drug efficacy against some parasite species and life-cycle stages, and side-effects on host cells due to non-selective drug delivery. Development of new drug classes is prohibitively expensive in both time and money, and there is therefore an increase in research aimed at prolonging the lifespan and effectiveness of current drugs. We have developed a set of tuneable vehicles able to deliver selectively both small molecular weight compounds as well as large biomoleculesinto nematodes, kinetoplastids and the intracellular stages of apicomplexan parasites.