Seminar Series

Recent Advances in the Synthesis and Applications of Non-Natural Amino Acids

Speaker

Professor Richard F W Jackson

Institute

Department of Chemistry The University of Sheffield, UK

Time & Place

Wed, 23 Mar 2016 12:00:00 NZDT in Room 531

All are welcome

Abstract

The talk will cover two distinct aspects of amino acid chemistry. In the first part I will discuss how understanding of the structure of organozinc halides has resulted in the development of a method for preparing enantiomerically pure amino acids in an aqueous environment using the Negishi reaction. In the second part, I will present very recent results on the synthesis and application of a stable analogue of that most challenging phosphorylated amino acid, phosphohistidine.

We use a range of experimental techniques, including gas phase structure determination of reactive intermediates, DFT calculations, and biological techniques for the characterisation of antibodies, as well as applications of organometallic chemistry to organic synthesis.