Synthesis of Nitrogen Mustards on Co(III), and Related Reaction Chemistry
Janadari Kariyawasam Final Ph.D. Seminar
Time & Place
Fri, 20 May 2016 14:00:00 NZST in Rutherford Room 531
All are welcome
The aim of synthesising the nitrogen mustard on the Co(III) metal centre is to develop better and safer synthetic routes to complexes of these cytotoxic nitrogen mustard molecules. These complexes are needed for incorporation the Ru(II)-Co(III) pro-drug systems of the kind shown schematically in Figure 1.
Photoinduced electron transfer from Ru(II) to Co(III), through a bridging ligand (L), has been shown to result in ligand release from the Co(III) centre.
The cytotoxic nitrogen mustard molecules are much less reactive when coordinated on to the Co(III) centre. We have explored the coordination chemistry required to prepare such systems and developed the functional group chemistry of these coordinated ligands.