Seminar Series

Natural Product-Inspired Toolbox for Protein-Protein Interactions: synthesis of new natural product like chemical species as probe for new therapeutics targets

Speaker

Professor Javed Iqbal

Institute

Founder and Chairman, Cosmic Therapeutics, Hyderabad Program Lead, Human Health & Well-being, RCAP International Council of Science, Kuala Lumpur, Malaysia

Time & Place

Wed, 13 Apr 2016 12:00:00 NZST in Rutherford Room 531

All are welcome

Abstract

Natural product-inspired molecules have found widespread use as tools in chemical biology in dissecting the molecular pathways for diseases. The molecular structural complexity of natural products limits their use as therapeutic agents owing to their poor phamacokinetics and difficulty in synthesis on a large scale.

Our research group have been engaged in developing molecular tools in search of new therapeutics targets by developing methodologies and protocols for the synthesis of natural product-inspired molecules. This talk will focus on our approach for the synthesis of highly potent anticancer drug Eribulin derived hybrid molecules which have been shown to be highly active anticancer molecules with novel properties as tools for new protein targets.