School of Physical and Chemical Sciences, Te Kura Matū Seminar Series

Automating Oligosaccharide Synthesis and Analysis

Speaker

Prof. Nicola L. B. Pohl

Institute

Department of Chemistry, Indiana University, USA

Time & Place

Tue, 05 Jun 2018 11:00:00 NZST in West 351

All are welcome

Abstract

Many advances in understanding the role of carbohydrates in biological systems are stalled by the lack of diverse and chemically well-defined glycan structures and methods to quickly and definitively identify such structures. Because these problems of carbohydrate synthesis and analysis are interrelated, we have taken a systems approach to tackling these challenges.  This talk will provide an overview of the current challenges in the development of solution-phase-based automated oligosaccharide protocols, with a particular focus on the use of light fluorous tags and including access to monosaccharide building blocks, and the development of robust de novocarbohydrate sequencing workflows. A new open-source approach to building automated synthesizers will also be discussed.

Biography

Nicola Pohl, professor of chemistry and the Joan and Marvin Carmack Chair in Bioorganic Chemistry, received her B.A. degree from Harvard College in 1991 and her Ph.D. in chemistry from the University of Wisconsin-Madison in 1997. Following an NIH Postdoctoral Fellowship in the Department of Chemical Engineering at Stanford University, she joined the faculty at Iowa State University in the fall of 2000. She was a professor of chemistry and of chemical and biological engineering and held the Wilkinson Professor of Interdisciplinary Engineering at Iowa State University before moving to Indiana University in summer 2012.

Pohl Research Group - http://www.indiana.edu/~pohllab/