SYNTHESIS OF N-GLYCANS FOR IMMUNOLOGICAL STUDIES
Sivasinthujah Paramasivam, PhD Chemistry Candidate
School of Physical and Chemical Sciences
Time & Place
Fri, 26 Jul 2019 11:00:00 NZST in Room 701, Level 7, WEST
All are welcome
Over the past few decades, immunologists have begun to try and develop vaccines against tumour cells. One of several approaches to developing an effective vaccine involves targeting a endocytic receptors on antigen-presenting cells, which results in enhanced antigen cross-presentation. These studies, the mannose receptor was used as an endocytic receptor. To date, there is no clear picture of the factors that are important in controlling antigen cross-presentation. This project therefore concerns the chemoenzymatic synthesis of defined glycopeptides and glycoproteins as chemical biology tools to help unravel the role(s) of the MR in antigen cross presentation.
This presentation will focus on the synthesis and semisynthesis of N-glycan donors, and ENGase catalysed glycosylation using the Fmoc-Asn-GlcNAz as an acceptor.