School of Physical and Chemical Sciences Te Kura Matū Seminar Series

SYNTHESIS OF N-GLYCANS FOR IMMUNOLOGICAL STUDIES

Speaker

Sivasinthujah Paramasivam, PhD Chemistry Candidate

Institute

School of Physical and Chemical Sciences

Time & Place

Fri, 26 Jul 2019 11:00:00 NZST in Room 701, Level 7, WEST

All are welcome

Abstract

Over the past few decades, immunologists have begun to try and develop vaccines against tumour cells. One of several approaches to developing an effective vaccine involves targeting a endocytic receptors on antigen-presenting cells, which results in enhanced antigen cross-presentation. These studies, the mannose receptor was used as an endocytic receptor. To date, there is no clear picture of the factors that are important in controlling antigen cross-presentation. This project therefore concerns the chemoenzymatic synthesis of defined glycopeptides and glycoproteins as chemical biology tools to help unravel the role(s) of the MR in antigen cross presentation.

This presentation will focus on the synthesis and semisynthesis of N-glycan donors, and ENGase catalysed glycosylation using the Fmoc-Asn-GlcNAz as an acceptor.