Chemical diversity through biotransformations
Institute of Pharmaceutical Sciences, Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
Time & Place
Wed, 25 Jul 2018 12:00:00 NZST in Jack Erskine Building Room 441
All are welcome
Diversity-oriented strategies are widespread in biosynthesis, or it may be more appropriate to state that biosynthesis is the archetype of diversity-oriented synthesis. We work towards the elucidation and application of diversity-oriented aspects of biosynthesis and biocatalysis, such as stereoselective phenolic coupling, chorismate-derived microbial products, or the use of multi purpose biocatalysts for C-C bond formation.
By using biosynthetic strategies we introduced novel biocatalytic and biomimetic syntheses of small bioactive molecules, e.g., HMG-CoA reductase inhibitors, antiviral compounds, and antibiotics. The long-term goal of this project is the identification of advantageous trajectories[3-4] for the synthesis of putative new bioactivities without the need for the synthesis of huge compound libraries.
 J. Bongaerts et al., Diversity-oriented production of metabolites derived from chorismate and their use in organic synthesis, Angew. Chem. 2011, 123, 7927.
 M. Müller, Chemical diversity through biotransformations, Current Opin. Biotechnol. 2004, 15, 591.
 M. Beigi et al., Regio- and Stereoselective Aliphatic–Aromatic Cross-Benzoin Reaction: Enzymatic Divergent Catalysis, Chem. Eur. J. 2016, 22, 13999.
 D. Conradt et al., Diversity in Reduction with Short-Chain Dehydrogenases: Tetrahydroxynaphthalene Reductase, Trihydroxynaphthalene Reductase, and Glucose Dehydrogenase, ChemCatChem 2015, 7, 3116.