School of Physical and Chemical Sciences, Te Kura Matū Seminar Series

Chemical diversity through biotransformations

Speaker

Michael Müller

Institute

Institute of Pharmaceutical Sciences, Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany

Time & Place

Wed, 25 Jul 2018 12:00:00 NZST in Jack Erskine Building Room 441

All are welcome

Abstract

Diversity-oriented strategies are widespread in biosynthesis, or it may be more appropriate to state that biosynthesis is the archetype of diversity-oriented synthesis. We work towards the elucidation and application of diversity-oriented aspects of biosynthesis and biocatalysis, such as stereoselective phenolic coupling, chorismate-derived microbial products,[1] or the use of multi purpose biocatalysts for C-C bond formation.

By using biosynthetic strategies we introduced novel biocatalytic and biomimetic syntheses of small bioactive molecules, e.g., HMG-CoA reductase inhibitors, antiviral compounds, and antibiotics.[2] The long-term goal of this project is the identification of advantageous trajectories[3-4] for the synthesis of putative new bioactivities without the need for the synthesis of huge compound libraries.

[1]  J. Bongaerts et al., Diversity-oriented production of metabolites derived from chorismate and their use in organic synthesis, Angew. Chem. 2011, 123, 7927.

[2]  M. Müller, Chemical diversity through biotransformations, Current Opin. Biotechnol. 2004, 15, 591.

[3]  M. Beigi et al., Regio- and Stereoselective Aliphatic–Aromatic Cross-Benzoin Reaction: Enzymatic Divergent Catalysis, Chem. Eur. J. 2016, 22, 13999.

[4]  D. Conradt et al., Diversity in Reduction with Short-Chain Dehydrogenases: Tetrahydroxynaphthalene Reductase, Trihydroxynaphthalene Reductase, and Glucose Dehydrogenase, ChemCatChem 2015, 7, 3116.

 

All Welcome