Synthetic glycomimetics to explore carbohydrate-specific adhesion of bacteria to surfaces
Prof Thisbe K. Lindhorst
Department of Organic Chemistry, Kiel University
Time & Place
Wed, 06 Mar 2019 12:00:00 NZDT in Room 701, Level 7, West
All are welcome
The carbohydrate-specific attachment (adhesion) of bacteria to cell surfaces often is the first step to infection. Therefore, we have a twofold interest in studying bacterial adhesion, first to combat infectious diseases by an anti-adhesion therapy, and second to understand principles of carbohydrate recognition. We take an approach from Biological Chemistry, where we design and synthesise specific glycomimetics and then test them in a biological context such as in bacterial adhesion-inhibition assays. The research of my group has been focused on multivalency effects and more recently on the investigation of rientational control of carbohydrate recognition. Our work contributes to a more conclusive understanding of the biological meaning of the glycome which, in addition to the genome and proteome of an organism, regulates fundamental processes of life.
Read more about Thisbe's group here.