Combating infectious diseases through structural and mechanistic studies
Ivanhoe K. H. Leung
School of Chemical Sciences, The University of Auckland
Time & Place
Fri, 19 Jul 2019 11:00:00 NZST in Room 701, West Building
All are welcome
2018 marked the 90th anniversary since Alexander Fleming first discovered penicillin. However, despite over 90 years of research, infectious diseases are still amongst the top ten leading causes of death worldwide. Infectious diseases are not only placing significant burden to developing nations, they could also spread at threatening pace globally, putting every nation and every person at risk. Our research is driven by the desire to understanding the molecular mechanisms that allow bacteria to survive. In this talk, we will discuss two of our recent projects in combating infectious diseases through structural, biochemical and computation approaches.
We will report our progress in understanding how Mycobacterium tuberculosis regulates the use of different carbon sources to survive inside our body during latent infection. We will also describe our work on the development of new chemical agents to tackle an emerging antibiotic resistance mechanism against colistin, an antibiotic of last resort.
Son, S. J.; Huang, R.; Squire, C. J.; Leung, I. K. H. MCR-1: A Promising Target for Structure-Based Design of Inhibitors to Tackle Polymyxin Resistance. Drug Discov. Today 2019, 24, 206–216.
Bhusal, R. P.; Patel, K.; Kwai, B. X. C.; Swartjes, A.; Bashiri, G.; Reynisson, J.; Sperry, J.; Leung, I. K. H. Development of NMR and Thermal Shift Assays for the Evaluation of Mycobacterium tuberculosis Isocitrate Lyase Inhibitors. Med. Chem. Commun. 2017, 8, 2155–2163.
Bhusal, R. P.; Bashiri, G.; Kwai, B. X. C.; Sperry, J.; Leung, I. K. H. Targeting Isocitrate Lyase for the Treatment of Latent Tuberculosis. Drug Discov. Today 2017, 22, 1008–1016.
Read about Ivanhoe Leung's research group here.