School of Physical and Chemical Sciences - Te Kura Matū Seminar Series

Assembly of complex outer membrane proteins in bacteria

Speaker

Iain Hay

Institute

Senior Lecturer, School of Biological Sciences, The University of Auckland

Time & Place

Wed, 16 Oct 2019 12:00:46 NZDT in Room 701, West Building

All are welcome

Abstract

More than a third of bacterial proteins are associated with the cellular envelope or must traverse a membrane to perform their function. Bacteria utilise a cooperative network of pathways in the biogenesis, assembly and insertion of proteins destined for the outer membrane. These proteins or protein assembles are essential for the viability parthenogenesis of all Gram-negative pathogens. The majority of proteins destined for the outer membrane are simple beta barrel porins, aided in their membrane transertion by the Beta-barrel Assembly Machinery (BAM), whereas more complex outer membrane proteins (for example, fimbrial ushers, secretion systems, capsule secretion pores) require additional mechanisms to assist their assembly within the envelope and membrane insertion. Here, using an array of biochemical and structural techniques, Dr Iain Hay will discuss several approaches he and his colleagues have used to try and unravel how these proteins assemble in to the cellular envelope and function.

All Welcome

Biography

Learn more about Dr Iain Hay here.