Mass spectrometry and X-ray crystallography reveal new insights into the biosynthesis of cofactor F420 and folic acid
Senior Research Fellow, Biological Sciences University of Auckland
Time & Place
Wed, 08 May 2019 12:00:00 NZST in Room 701, Level 7, West Building
All are welcome
Cofactor F420 plays critical roles in primary and secondary metabolism in a range of bacteria and archaea as a low-potential hydride transfer agent. It mediates a variety of important redox transformations involved in bacterial persistence, antibiotic biosynthesis, pro-drug activation and methanogenesis. The majority of my research over the past 10 years has been directed towards understanding the roles and importance of F420 in the metabolism of various bacteria. In this talk, I will present our recent findings on F420 biosynthesis and discuss how these results have also shed light on the biosynthesis of another class of cofactors, namely folic acids.
Gharder's research investigates the molecular basis of complex biological mechanisms with themes in microbial biochemistry, physiology and pathogenesis. He uses a multidisciplinary approach and seeks to use the latest state-of-the-art methods in molecular/structural biology, biochemistry, computational biology, microbial infection models, and synthetic chemistry. A major focus of his research is on novel metabolic targets for fighting pathogenic bacteria, to understand their mechanism of action, and to combat the worldwide issues of microbial persistence and resistance. Read more about Gharder's research here.