Senior LecturerTimothy Allison
Chemistry Seminar Co-ordinator
Julius von Haast 517
Phone: +6433693034
Internal Phone: 93034
Qualifications & Memberships
Research Interests
I investigate how proteins work and assemble using chemical and structural biology approaches incorporating native mass spectrometry and protein crystallography. I have a particular interest in the enzymes involved in glycan biosynthesis, and alongside this, fundamental interests in the technical workings of the methodologies I employ.
Recent Publications
- Allison TM., Degiacomi MT., Marklund EG., Jovine L., Elofsson A., Benesch JLP. and Landreh M. (2022) Complementing machine learning-based structure predictions with native mass spectrometry. Protein Science 31(6) http://dx.doi.org/10.1002/pro.4333.
- Given FM., Moran F., Johns AS., Titterington JA., Allison TM., Crittenden DL., Johnston JM. and Tsai FT. (2022) The structure of His-tagged Geobacillus stearothermophilus purine nucleoside phosphorylase reveals a 'spanner in the works'. Acta Crystallographica Section F: Structural Biology Communications 78: 416-422. http://dx.doi.org/10.1107/S2053230X22011025.
- Yen HY., Abramsson ML., Agasid MT., Lama D., Gault J., Liko I., Kaldmäe M., Saluri M., Qureshi AA. and Suades A. (2022) Electrospray ionization of native membrane proteins proceeds via a charge equilibration step. RSC Advances 12(16): 9671-9680. http://dx.doi.org/10.1039/d2ra01282k.
- Abramsson ML., Sahin C., Hopper JTS., Branca RMM., Danielsson J., Xu M., Chandler SA., Österlund N., Ilag LL. and Leppert A. (2021) Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry. JACS Au 1(12): 2385-2393. http://dx.doi.org/10.1021/jacsau.1c00458.
- Sahin C., Österlund N., Leppert A., Johansson J., Marklund EG., Benesch JLP., Ilag LL., Allison TM. and Landreh M. (2021) Ion mobility-mass spectrometry shows stepwise protein unfolding under alkaline conditions. Chemical Communications 57(12): 1450-1453. http://dx.doi.org/10.1039/d0cc08135c.