Qualifications & Memberships
Research Interests
My research interest is in understanding organic reactions, particularly those of value in synthesis and or biochemistry. Many of our studies have involved the timing of molecular events and the difference in energy of competing processes including: strained small ring opening and molecular rearrangement, factors responsible for facial selection in cycloaddition reactions and - reactions at carbonyls, and the use of chiral templates in inducing selection. Other interests include molecular modelling studies (ab initio studies of strained ring rearrangements, carbohydrate solution properties, macrocyclic conformational problems and protein structure) and Cataract research (a joint project with Professor Andrew Abell and colleagues at Lincoln focuses in development of calpain inhibitors).
Recent Publications
- Coxon JM. (2017) Molecular Rearrangements. Organic Reaction Mechanisms 2014: An Annual Survey Covering the Literature Dated January to December 2014: 621-711. http://dx.doi.org/10.1002/9781118941829.ch12.
- Coxon JM. (2016) Molecular rearrangements. Organic Reaction Mechanisms 2013: An annual survey covering the literature dated January to December 2013: 519-607. http://dx.doi.org/10.1002/9781118707838.ch12.
- Coxon JM. (2014) Molecular Rearrangements. Organic Reaction Mechanisms 2011: An annual survey covering the literature dated January to December 2011: 477-538. http://dx.doi.org/10.1002/9781118560273.ch13.
- Jones SA., Duncan J., Aitken SG., Coxon JM. and Abell AD. (2014) The preparation of macrocyclic calpain inhibitors by ring closing metathesis and cross metathesis. Australian Journal of Chemistry 67(8-9): 1257-1263. http://dx.doi.org/10.1071/CH14121.
- Morton JD., Lee HYY., McDermott JD., Robertson LJG., Bickerstaffe R., Jones MA., Coxon JM. and Abell AD. (2013) A macrocyclic calpain inhibitor slows the development of inherited cortical cataracts in a sheep model. Investigative Ophthalmology and Visual Science 54(1): 389-395. http://dx.doi.org/10.1167/iovs.12-11088.