Dan Foley

Chemistry LecturerDaniel Foley

Beatrice Tinsley 323
Internal Phone: 90479


Research Interests

My research is focused on the development of new synthetic methods and strategies that are intended for application in early-stage drug discovery efforts. I am especially interested in identifying enabling synthetic chemistries that can increase the versatility of fragment based-drug discovery (FBDD) programmes. Such synthetic technologies may ensure that fragments can be advanced towards higher affinity compounds (e.g. leads, drugs and chemical tools) in predictable, modular, and additive ways.

Go to this link for my personal website: https://foleynz.wixsite.com/foleylab

Recent Publications

  • Karageorgis G., Foley DJ., Laraia L. and Waldmann H. (2020) Principle and design of pseudo-natural products. Nature Chemistry http://dx.doi.org/10.1038/s41557-019-0411-x.
  • Laraia L., Garivet G., Foley DJ., Kaiser N., Müller S., Zinken S., Pinkert T., Wilke J., Corkery D. and Pahl A. (2020) Image-Based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor. Angewandte Chemie - International Edition http://dx.doi.org/10.1002/anie.201913712.
  • Zhang R., McIntyre PJ., Collins PM., Foley DJ., Arter C., von Delft F., Bayliss R., Warriner S. and Nelson A. (2019) Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase. Chemistry - A European Journal 25(27): 6831-6839. http://dx.doi.org/10.1002/chem.201900815.
  • Aimon A., Karageorgis G., Masters J., Dow M., Craven PGE., Ohsten M., Willaume A., Morgentin R., Ruiz-Llamas N. and Lemoine H. (2018) Realisation of small molecule libraries based on frameworks distantly related to natural products. Organic and Biomolecular Chemistry 16(17): 3160-3167. http://dx.doi.org/10.1039/c8ob00688a.
  • Robke L., Rodrigues T., Schröder P., Foley DJ., Bernardes GJL., Laraia L. and Waldmann H. (2018) Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors. Tetrahedron 74(35): 4531-4537. http://dx.doi.org/10.1016/j.tet.2018.07.021.