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Chemistry LecturerDaniel Foley

West 852
Internal Phone: 90479


Research Interests

My research is focused on the development of new synthetic methods and strategies that are intended for application in early-stage drug discovery efforts. I am especially interested in identifying enabling synthetic chemistries that can increase the versatility of fragment based-drug discovery (FBDD) programmes. Such synthetic technologies may ensure that fragments can be advanced towards higher affinity compounds (e.g. leads, drugs and chemical tools) in predictable, modular, and additive ways.

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Recent Publications

  • Zhang R., McIntyre PJ., Collins PM., Foley DJ., Arter C., von Delft F., Bayliss R., Warriner S. and Nelson A. (2019) Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase. Chemistry - A European Journal 25(27): 6831-6839.
  • Aimon A., Karageorgis G., Masters J., Dow M., Craven PGE., Ohsten M., Willaume A., Morgentin R., Ruiz-Llamas N. and Lemoine H. (2018) Realisation of small molecule libraries based on frameworks distantly related to natural products. Organic and Biomolecular Chemistry 16(17): 3160-3167.
  • Robke L., Rodrigues T., Schröder P., Foley DJ., Bernardes GJL., Laraia L. and Waldmann H. (2018) Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors. Tetrahedron 74(35): 4531-4537.
  • Foley DJ., Craven PGE., Collins PM., Doveston RG., Aimon A., Talon R., Churcher I., von Delft F., Marsden SP. and Nelson A. (2017) Synthesis and Demonstration of the Biological Relevance of sp3-rich Scaffolds Distantly Related to Natural Product Frameworks. Chemistry - A European Journal 23(60): 15227-15232.
  • Foley DJ., Nelson A. and Marsden SP. (2016) Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose? Angewandte Chemie - International Edition 55(44): 13650-13657.