The main focus of our research is in the field of Organic Synthesis, particulalry applied to carbohydrates. Sugars, and in particular oligosaccharides, play key roles in a plethora of biological processes and chemical synthesis allows us to make molecules that will either enable us to increase our understanding of these processes, or perhaps even more importantly enable us to interfere with undesired processes. So, as Organic Chemists, we are not only interested in synthesis for its own sake, but also in the potential that our efforts can have in the fields of Glycoscience and Medicine, be it by accessing biologically important carbohydrates, or by the synthesis of mimics of sugars as therapeutic agents. As well as mainstream synthesis we are also interested in synthetic access to proteins that bear particular defined carbohydrate structures: structurally defined glycoproteins, and we have recently expanded our expertise into the field of molecular biology in order to develop more efficient biocatalysts to achieve this aim. This research interest led to the launch of a spinout company, Glycoform (http://www.glycoform.co.uk) in 2002.
- Qiu X. and Fairbanks AJ. (2020) Direct Synthesis of para-Nitrophenyl Glycosides from Reducing Sugars in Water. Organic Letters 22(6): 2490-2493. http://dx.doi.org/10.1021/acs.orglett.0c00728.
- Wang X., Ashhurst AS., Dowman LJ., Watson EE., Li HY., Fairbanks AJ., Larance M., Kwan A. and Payne RJ. (2020) Total Synthesis of Glycosylated Human Interferon-γ.. Org Lett http://dx.doi.org/10.1021/acs.orglett.0c02401.
- Fairbanks AJ. (2019) Chemoenzymatic synthesis of glycoproteins. Current Opinion in Chemical Biology 53: 9-15. http://dx.doi.org/10.1016/j.cbpa.2019.05.015.
- Fairbanks AJ. (2019) Meet the Board of ChemistryOpen: Antony J. Fairbanks. ChemistryOpen 8(2): 188-189. http://dx.doi.org/10.1002/open.201900020.
- Marqvorsen MHS., Paramasivam S., Doelman W., Fairbanks AJ. and Van Kasteren SI. (2019) Efficient synthesis and enzymatic extension of an: N -GlcNAz asparagine building block. Chemical Communications 55(36): 5287-5290. http://dx.doi.org/10.1039/c9cc02051a.