The main focus of our research is in the field of Organic Synthesis, particulalry applied to carbohydrates. Sugars, and in particular oligosaccharides, play key roles in a plethora of biological processes and chemical synthesis allows us to make molecules that will either enable us to increase our understanding of these processes, or perhaps even more importantly enable us to interfere with undesired processes. So, as Organic Chemists, we are not only interested in synthesis for its own sake, but also in the potential that our efforts can have in the fields of Glycoscience and Medicine, be it by accessing biologically important carbohydrates, or by the synthesis of mimics of sugars as therapeutic agents. As well as mainstream synthesis we are also interested in synthetic access to proteins that bear particular defined carbohydrate structures: structurally defined glycoproteins, and we have recently expanded our expertise into the field of molecular biology in order to develop more efficient biocatalysts to achieve this aim. This research interest led to the launch of a spinout company, Glycoform (http://www.glycoform.co.uk) in 2002.
- Alexander SR., Williams GM., Brimble MA. and Fairbanks AJ. (2018) A double-click approach to the protecting group free synthesis of glycoconjugates. ORGANIC & BIOMOLECULAR CHEMISTRY 16(8): 1258-1262. 10.1039/c8ob00072grsc.li/obc.
- Alexander SR., Williams GM., Brimble MA. and Fairbanks AJ. (2018) A double-click approach to the protecting group free synthesis of glycoconjugates. Organic and Biomolecular Chemistry 16(8): 1258-1262. http://dx.doi.org/10.1039/c8ob00072g.
- Fairbanks AJ. (2018) Synthetic and semi-synthetic approaches to unprotected N-glycan oxazolines. Beilstein Journal of Organic Chemistry 14: 416-429. http://dx.doi.org/10.3762/bjoc.14.30.
- Suthagar K., Jiao W., Munier-Lehmann H. and Fairbanks AJ. (2018) Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis. Carbohydrate Research 457: 32-40. http://dx.doi.org/10.1016/j.carres.2018.01.001.
- Alexander SR., Lim D., Amso Z., Brimble MA. and Fairbanks AJ. (2017) Protecting group free synthesis of glycosyl thiols from reducing sugars in water; application to the production of N-glycan glycoconjugates. Organic and Biomolecular Chemistry 15(10): 2152-2156. http://dx.doi.org/10.1039/c7ob00112f.