Heart disease and strokes are caused by the collection of cholesterol filled cells within the wall of arteries called atherosclerotic plaques. Oxidised cholesterol particles formed in the plaque causes cells to die and the plaque to rupture so triggering blood clot formation. This results in a heart attack if the clot stops the supply of blood to the heart, or a stroke if the supply to parts of the brain is affected. Our past research has described how a white blood cell generated antioxidant called dihydroneopterin protects the cells from oxidised cholesterol and inhibits the formation of oxidised LDL. Our research is now examining how the cell death is initiated by oxidized cholesterol particles and identifying the key control points in the process. The understanding of the cellular death mechanism is essential for the development of new treatments to prevent plaque formation. 

Key qualifications and skills

Biochemistry or cell biology or organic chemistry

Does the project come with funding

Yes - research costs are covered

Final date for receiving applications

Ongoing

Keywords

Heart Disease, stroke, inflammation, health, Imaging