Determining insulin injection loss
Ph.D. Student Alex McHugh
Department of Mechanical Engineering, University of Canterbury
Time & Place
Tue, 14 Dec 2021 13:20:00 NZDT in E12, Engineering Core
For people with diabetes, managing blood glucose requires reliable delivery of insulin, a hormone which regulates glucose levels. Insulin can be delivered subcutaneously (under the skin) for prolonged action over a longer period of time than intravenous delivery. Needle-free jet-injectors deliver insulin as a high-pressure jet of liquid, without requiring needle use, but the volume of insulin absorbed varies due to losses associated with the delivery method.
This study aimed to use measured plasma data from an oral glucose tolerance test (a standard metabolic test) to determine jet-injection losses. Validated models are used to identify the input injection value which best explains the measured data. Optimal parameter identification suggests losses of up to 22% of the nominal subcutaneous dose. The degree of loss varies between subjects and between trials on the same subject. Insulin fit accuracy improves where loss greater than 5% is identified, relative to where delivery loss is not modelled.
All are Welcome!
Supervisor: Distinguished Professor Geoff Chase