Computational Models of Neurovascular Coupling
Katharina Dormanns, PhD Candidate
Time & Place
Tue, 23 Feb 2016 10:45:00 NZDT in Undercroft Meeting Room 101 (below the main library)
Neurovascular coupling (NVC) describes the ability of the vasculature to regulate cerebral perfusion dependent on neuronal activity. Neurons, glia and vascular cells, collectively known as a neurovascular unit (NVU), provide this important and complex mechanism.
To simulate NVC with a high spatial and temporal resolution our research group has developed a numerical model that is able to describe the process of NVC from neuronal activation to vascular response and hence cerebral blood flow regulation. A space-filling model of a vascular tree (H- tree) that bifurcates into a fine capillary is used to globally couple multiple NVU models via the vasculature (see figure).
The model facilitates the investigation of the influence of uni- and bidirectional coupling with the vasculature under normal and pathological conditions in a tissue slice consisting of up to 4096 NVUs (corresponding to 2.5 cm × 2.5 cm of cerebral tissue).