Elevated blood sugar concentrations (hyperglycaemia) commonly occur in very premature infants in neonatal intensive care, and have been associated with increased mortality and worsened outcomes. Insulin can be used to treat hyperglycaemia, but current clinical practice worldwide often results in dangerously low blood sugar (hypoglycaemia). This research uses mathematical models of glucose-insulin physiology and statistical forecasting to determine an insulin dosage that is safe and effective. This model-based protocol is implemented as a tablet-based application, and is used in neonatal intensive care units in New Zealand and Hungary.
- Davidson SM., Uyttendaele V., Pretty CG., Knopp JL., Desaive T. and Chase JG. (2020) Virtual patient trials of a multi-input stochastic model for tight glycaemic control using insulin sensitivity and blood glucose data. Biomedical Signal Processing and Control 59 http://dx.doi.org/10.1016/j.bspc.2020.101896.
- Kim KT., Knopp J., Dixon B. and Chase JG. (2020) Mechanically ventilated premature babies have sex differences in specific elastance: A pilot study. Pediatric Pulmonology 55(1): 177-184. http://dx.doi.org/10.1002/ppul.24538.
- Kim KT., Morton S., Howe S., Chiew YS., Knopp JL., Docherty P., Pretty C., Desaive T., Benyo B. and Szlavecz A. (2020) Model-based PEEP titration versus standard practice in mechanical ventilation: A randomised controlled trial. Trials 21(1) http://dx.doi.org/10.1186/s13063-019-4035-7.
- Knopp JL. and Chase JG. (2020) Clinical Recommendations for Managing the Impact of Insulin Adsorptive Loss in Hospital and Diabetes Care. Journal of Diabetes Science and Technology http://dx.doi.org/10.1177/1932296820915875.
- Morton SE., Knopp JL., Chase JG., Möller K., Docherty P., Shaw GM. and Tawhai M. (2020) Authors’ Response to Drs. Ece Salihoglu and Ziya Salihoglu’s Letter to the Editor. Annals of Biomedical Engineering 48(1): 2-3. http://dx.doi.org/10.1007/s10439-019-02339-5.