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A project-orientated introduction to dynamic modelling in physiology and the life sciences. Major topics include the modelling of the fluid flow, mass exchange and feedback auto-regulation as they are utilised throughout the human body. There is a particular focus on the cardiovascular (heart), renal (kidney) and cerebral systems (brain), representing three of the main organ groups in the human body, and in particular on how fundamental engineering sciences and mathematics can be used to model their behaviour to provide better understanding, as well as to engineer new therapies and medical detection methods.