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This course is designed to help you to understand how different proteins function and how biochemists seek to investigate protein structure and function. The course aims to introduce you to modern biochemical ideas and research, and will include a substantial amount of reading from the biochemical literature, as well as from your standard textbook.
The course is intended to complement courses such as BCHM306, BCHM338, BCHM339, BCHM381, BIOL330, BIOL313. During the course our aim is to encourage and provide advice and feedback to enable you to develop skills in written and oral communication, and in the efficient acquisition of scientific information.
As a student in this course, I will develop the ability to: analyse and critically interpret experimental data (assessment task: tutorial data analysis exercises, test, exam).explain, with detailed examples, how nature uses proteins and the relationship between a protein function and protein structure (assessment task: test, exam)explain the function of cellular membranes and the proteins that facilitate the transport of molecules and signalling processes across these membranes. (assessment task: exam)present complex scientific ideas in a written form that can be understood by a wide audience (assessment task: review topic relevant to protein chemistry and present a research proposal that involves a partnership with a local iwi, as part of in term assessment).provide examples to demonstrate an understanding of the scientific practice and principles of macromolecular science (assessment task: review, proposal and exam). Synthesise and critically evaluate primary scientific literature to generate a clear and concise argument in support of a perspective (assessment task: evaluation of a research paper, as part of in term assessment).Transferable Skills Register As a student in this course, I will develop the following skills: Experience in analysing protein science data generated using a variety of methods. We will have tutorials looking at the analysis of protein science data, and you will be given the opportunity to analyse novel data. (this skill maps to the UC attribute: Critically competent)Critical synthesis of information. In everyday life and in many job situations you will be required to read information from different sources, construct your own understanding and shape your own viewpoint. In tutorials, we solve current problems in protein science and/or discuss recent protein science research papers in a group environment. Together, these will develop your abilities to assess the quality of the information, and how methods are applied to research. (this skill maps to the UC attributes: Critically competent and Employable, innovative and enterprising)Communicate science (spoken and written) to specialists and non-specialists in the general community, including iwi. In a tutorial and via in term assessment, we will consider the importance of partnership with Māori culture in developing research in New Zealand and appreciate how to engage and communicate effectively with iwi. (this skill maps to UC attributes: Biculturally competent and confident, Engaged with the community, and Globally aware)Appreciate how to commercialise new ideas relevant to protein science. In lectures, we will cover issues relevant to the biotechnology industry and consider the pathways to commercialisation of your own ideas. (this skill maps to UC attribute: Employable, innovative and enterprising)
BCHM253/BIOL253 and BCHM222. RP: BCHM202/BIOL231, BCHM206/CHEM242, BCHM212/CHEM212.
BCHM202/BIOL231, BCHM206/CHEM242, BCHM212/CHEM212.
Students must attend one activity from each section.
Electronic Distribution of Course MaterialAll course material will be distributed on Learn. This will include* course notices* lecture handouts that will be available before the lectures.* audio recordings of lectures (using ECHO360)SchedulePROTEIN STRUCTURE AND FUNCTION (14 lectures & 6 tutorials, terms 1 and 2)This section will start off with a review session covering the basic biological macromolecules before moving onto protein chemistry. We will learn about how proteins fold physically and biologically, as well as the how proteins unfold and misfold and the consequences of protein misfolding and aggregation. We will also cover methods for investigating protein interactions and protein structures. Lastly, we will work through case studies on how we apply various methods to understand how proteins function.Lecturer: Vanessa Morris (8 lectures) and then Ren Dobson (6 lectures) (contact details as above).Entrepreneurialism and COMMERICIALISATION (2 lectures, term 2)There are many ways to develop a scientific career. One exciting avenue is to commercialise your own ideas, either as your own start-up, or as part of a company (such as a CRI) that is commercialising an idea developed in house. We will consider topics relevant to the commercialisation of scientific ideas, including: how to develop/recognise a new idea for a commercial outcome; appreciating intellectual property; and, appreciate the various pathways to commercialisation. We will hear from a leader in the biotechnology industry and reflect on a case study relevant to their experiences.Lecturers: Ren Dobson (as above), Rachel Wright (firstname.lastname@example.org), plus a guest lecturer from industry.MEMBRANE PROTEINS (8 lectures & 3 tutorials, term 2)Membrane proteins. This section will build on the bioenergetic concepts that you learnt in the oxidative phosphorylation and photosynthesis sections of BCHM111 and BCHM222 and will be applied to membrane transport proteins. A number of these proteins will be covered, including the Na+/K+ ATPase, the H+ ATPase, the Ca2+ ATPase, Na+ and K+ ion channels and Na+/H+ antiporters. Signalling processes across membranes. In the tutorials, you will be given experimental data and that will allow you to identify specific proteins from that data and then devise a model to suggest how these may act in concert to enable an organism to survive an environmental stress.Lecturer: Ashley Garrill
and Vanessa Morris
Nelson, David L. , Cox, Michael M., Lehninger, Albert L;
Lehninger principles of biochemistry;
W.H. Freeman, 2017.
Domestic fee $910.00
International fee $4,438.00
* All fees are inclusive of NZ GST or any equivalent overseas tax, and do not include any programme level discount or additional course-related expenses.
For further information see
School of Biological Sciences.