Constantine Zakkaroff

Senior LecturerConstantine Zakkaroff

Meremere 516
Internal Phone: 93879
My teaching is focused on object-oriented systems development and data management. My research is in the area of large-scale physiological modelling.

Qualifications

Research Interests

Dr Zakkarof is a researcher with experience in cardiovascular image analysis, medical image registration and visualisation. He received his BSc and MSc degrees in computer science from the University of Canterbury, New Zealand, and his PhD from the University of Leeds, United Kingdom. His current research interests are large scale physiological simulation, and high performance computing. Dr Zakkaroff is developing the Coupled Arterial Cells project. At its core, this project has a massively parallel, multi-scale framework for modelling paracrine signalling. The project focuses on the investigation of the relationship between micro-scale cellular dynamics and the resulting emergent macro-scale behaviour as it is exemplified by the growth of atherosclerotic plaques. This approach to the exploration of large-scale emergent behaviour is capable of providing invaluable insights into the onset of coronary heart disease. In silico simulations enable the rapid exploration and pruning of the parameter search space for the refinement and integration of micro-level models into biologically realistic macro-scale models. The in silico simulation provide the opportunity to perform physiological experiments which are impossible in the in vivo or in vitro settings.

Recent Publications

  • Dowding S., Plank MJ., Zakkaroff C. and David T. (2018) The astrocyte-neuron lactate shuttle’s role in neurovascular coupling. Queenstown: 36th International Australasian Winter Conference on Brain Research, 25 Aug 2018.
  • Dowding S., Zakkaroff C., Moore S. and David T. (2018) Coronary smooth muscle cell calcium dynamics: Effects of bifurcation angle on atheroprone conditions. Frontiers in Physiology 9(OCT) http://dx.doi.org/10.3389/fphys.2018.01528.
  • Kenny A., Zakkaroff C., Plank M. and David T. (2018) Massively parallel simulations of neurovascular coupling with extracellular diffusion. Journal of Computational Science 24: 116-124. http://dx.doi.org/10.1016/j.jocs.2017.07.001.
  • Zakkaroff C., Biglands JD., Greenwood JP., Plein S., Boyle RD., Radjenovic A. and Magee DR. (2018) Patient-specific coronary blood supply territories for quantitative perfusion analysis. Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization 6(2): 137-154. http://dx.doi.org/10.1080/21681163.2016.1192003.
  • Zakkaroff C., Moore S., Dowding S. and David T. (2017) 3D time-varying simulations of Ca2+ dynamics in arterial coupled cells: A massively parallel implementation. International Journal for Numerical Methods in Biomedical Engineering 33(2) e02786 http://dx.doi.org/10.1002/cnm.2786.