Qualifications & Memberships
Research in our lab focuses on the structure, function and inhibition of key enzymes involved in infection and disease. We are also interested in the evolution of enzyme function, and conversely its design and manipulation.
We study a variety of enzymes: from those responsible for the biosynthesis of amino acids, in particular lysine, since these are validated drug targets; to glycolytic enzymes, such as pyruvate kinase, since these are tractable model systems to understand enzyme allostery. The list is ever increasing.
A common theme in the lab is the role protein-protein interactions in a variety of biological systems, mostly derived from bacteria, but more recently including eukaryotic proteins involved in cancer, where we hope to address the twin problems of how and why proteins form complexes and the functional consequences of these associations.
- Atkinson SC., Dogovski C., Wood K., Griffin MDW., Gorman MA., Hor L., Reboul CF., Buckle AM., Wuttke J. and Parker MW. (2018) Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target. Structure 26(7): 948-959.e5. http://dx.doi.org/10.1016/j.str.2018.04.014.
- Crowther JM., Allison JR., Smolenski GA., Hodgkinson AJ., Jameson GB. and Dobson RCJ. (2018) The self-association and thermal denaturation of caprine and bovine β-lactoglobulin. European Biophysics Journal 47(7): 739-750. http://dx.doi.org/10.1007/s00249-018-1300-8.
- Foglizzo M., Middleton AJ., Burgess AE., Crowther JM., Dobson RCJ., Murphy JM., Day CL. and Mace PD. (2018) A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes. Nature Communications 9(1) http://dx.doi.org/10.1038/s41467-018-06186-1.
- Gilkes JM., Frampton RA., Smith GR. and Dobson RCJ. (2018) Potential pathogenicity determinants in the genome of ‘Candidatus Liberibacter solanacearum’, the causal agent of zebra chip disease of potato. Australasian Plant Pathology 47(2): 119-134. http://dx.doi.org/10.1007/s13313-018-0546-z.
- Glikes JM., Frampton RA., Smith GR. and Dobson RCJ. (2018) Potential pathogenicity determinants in the genome of 'Candidatus Liberibacter solanacearum', the causal agent of zebra chip disease of potato. Australasian Plant Pathology http://dx.doi.org/10.1007/s13313-0180546-z.