The reactivity of small, biologically relevant molecules when they are bound to metal ions.
The reactivities of small molecules are modified when they are coordinated to metal ions. Nature exploits these effects on reactivity in the construction of many enzyme active sites, and thereby achieves catalysis of reactions which would otherwise proceed too slowly to be useful in a living system. As a result of our studies, we hope to gain insights in to the ways in which nature achieves and controls such chemical reactions. These studies may also point to the ways in which such chemistry may go astray, for example through undesirable reactions induced by UV light.