UC Spark

Dr Timothy Bryan Francis Woodfield

Mechanical Engineering
Phone: +64 3 364 2987 ext. 7384
 Office: Mechanical Engineering E537

Fields of Research

  • Biodegradable porous scaffolds
  • Biomaterials
  • Bone tissue engineering
  • Cartilage tissue engineering
  • Rapid prototyping of biomaterials
  • Replacing damaged tissue with patients own cells
  • Skin tissue engineering
  • Stem cells
  • Tissue Engineering
  • Total joint arthroplasty

Researcher Summary

Research interests include:
- Scaffold/biomaterial design for functional tissue-engineered implants: cell-biomaterial interactions; articular cartilage, bone, neural/nerve tissue engineering; smart/instructive biomaterials (i.e. inductive materials/architectures, growth factor/drug release, cell free solutions); engineered porous scaffold architectures (topology optimisation); anisotropic/biphasic scaffold design; biodegradation and mechanical function with respect to tissue integration; in vitro/in vivo models using committed, progenitor and stem cells.
- Solid Free-from Fabrication (SFF) of porous biomaterials: engineered porous scaffold architectures; development of SFF “friendly” biomaterials; SFF of porous polymeric, Ti/Ti-alloys, and ceramic biomaterials; electro-spinning; bone in-growth surfaces; bio-manufacturing/cell printing; clinical applications for customised implants/joint reconstruction.
- Mechanobiology of cells/connective tissues: measurement/optimisation of nutrient gradients (e.g. oxygen, glucose) and their subsequent effects on tissue formation; cellular responses to mechanical stimuli; computational/in vitro models; bioreactor design.
- Orthopaedic applications: total joint arthroplasty; proprioceptive ability of patients following TKA; wheelchair propulsion ability in SCI subjects; spinal fusion devices; biodegradable conduits for nerve/spinal cord regeneration; cell therapy/tissue engineering applications in regenerative medicine.

Subject Area: Disciplines

Affiliations

Publications


  • Murray, L.M., Nock, V., Alkaisi, M.M., Lee, J.J.M. and Woodfield, T.B.F. (2012) Fabrication of polymeric substrates with micro- and nanoscale topography bioimprinted at progressive cell morphologies. Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures: Processing, Measurement, and Phenomena 30: 06F902. http://dx.doi.org/10.1116/1.4758759. (Journal Article)
  • Lang, M., Chen, X.Q., Wang, W.H. and Woodfield, T. (2012) Injection system for cellular assembly of 3D bio-tissue engineered constructs. Seoul, Korea: 8th IEEE International Conference on Automation Science and Engineering (CASE), 20-24 Aug 2012. 287-292. http://dx.doi.org/10.1109/CoASE.2012.6386394. (Conference Contribution - Paper in published proceedings)
  • Khan-Edmundson, A., Rodgers, G.W., Woodfield, T.B.F., Hooper, G.J. and Chase, J.G. (2012) Tissue attenuation characteristics of acoustic emission signals for wear and degradation of total hip arthoplasty implants. Budapest, Hungary: 8th IFAC Symposium on Biological and Medical Systems (BMS12), 29-31 Aug 2012. In Biological and Medical Systems 8(1) 355-360. http://dx.doi.org/10.3182/20120829-3-HU-2029.00046. (Conference Contribution - Paper in published proceedings)
  • Nguyen, T.L., Staiger, M.P., Dias, G.J. and Woodfield, T.B.F. (2011) A novel manufacturing route for fabrication of topologically-ordered porous magnesium scaffolds. Advanced Engineering Materials 13(9): 872-881. http://dx.doi.org/10.1002/adem.201100029. (Journal Article)
  • Waterman, J., Pietak, A., Birbilis, N., Woodfield, T., Dias, G. and Staiger, M.P. (2011) Corrosion resistance of biomimetic calcium phosphate coatings on magnesium due to varying pretreatment time. Materials Science and Engineering B 176(20): 1756-1760. http://dx.doi.org/10.1016/j.mseb.2011.06.021. (Journal Article)
  • Shadanbaz, S., Pietak, A., Staiger, M.P., Woodfield, T. and Dias, G.J. (2011) In situ crystallisation - a novel calcium phosphate coating technique on pure magnesium: in vitro corrosion protection analysis. Queenstown, New Zealand: 21st Annual Australasian Society for Biomaterials & Tissue Engineering (ASBTE) Conference, 27-29 Apr 2011. (Conference Contribution - Paper in published proceedings)
  • Waterman, J., Kirkland, N., Hartshorn, R., Birbilis, N., Woodfield, T., Dias, G. and Staiger, M.P. (2011) NMR studies on the complex behaviour of magnesium and HEPES for in vitro testing. Queenstown, New Zealand: 21st Annual Australasian Society for Biomaterials & Tissue Engineering (ASBTE) Conference, 27-29 Apr 2011. (Conference Contribution - Paper in published proceedings)
  • Nguyen, T., Staiger, M.P., Dias, G. and Woodfield, T. (2011) Relationship between surface roughness and corrosion rate of pure magnesium biomaterials. Queenstown, New Zealand: 21st Annual Australasian Society for Biomaterials & Tissue Engineering (ASBTE) Conference, 27-29 Apr 2011. (Conference Contribution - Paper in published proceedings)
  • Kirkland, N.T., Kolbeinsson, I., Dias, G.J., Woodfield, T. and Staiger, M.P. (2011) Synthesis and properties of topologically-ordered porous magnesium. Materials Science and Engineering B 176(20): 1666-1672. http://dx.doi.org/10.1016/j.mseb.2011.04.006. (Journal Article)
  • Walker, J., Staiger, M.P., Woodfield, T. and Dias, G. (2011) The development of an intermuscular model to investigate the biocompatibility of magnesium alloys. Queenstown, New Zealand: 21st Annual Australasian Society for Biomaterials & Tissue Engineering (ASBTE) Conference, 27-29 Apr 2011. (Conference Contribution - Paper in published proceedings)
  • Lang, M., Wang, W.H., Chen, X.Q. and Woodfield, T. (2010) Automated 3D scaffold printing and seeding. Toronto, Ontario, Canada: The 6th Annual IEEE International Conference on Automation Science and Engineering, 21-24 Aug 2010. 786-791. (Conference Contribution - Paper in published proceedings)
  • Kirkland, N.T., Birbilis, N., Walker, J., Woodfield, T., Dias, G.J. and Staiger, M.P. (2010) In-vitro dissolution of magnesium-calcium binary alloys: Clarifying the unique role of calcium additions in bioresorbable magnesium implant alloys. Journal of Biomedical Materials Research Part B: Applied Biomaterials 95B(1): 91-100. http://dx.doi.org/10.1002/jbm.b.31687. (Journal Article)
  • Staiger, M.P., Kirkland, N.T., Kolbeinsson, I., Walker, J., Dias, G. and Woodfield, T.B.F. (2009) A Manufacturing Route For Cellular Magnesium With Ordered Architecture Aimed At Orthopaedic Applications. The University of New South Wales, Sydney, Australia: 19th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), 21-23 Jan 2009. (Conference Contribution - Abstract)
  • Kirkland, N.T., Staiger, M.P., Walker, J., Dias, G. and Woodfield, T.B.F. (2009) Biocompatibility screening methods for magnesium alloys in orthopaedic applications. The University of New South Wales, Sydney, Australia: 19th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), 21-23 Jan 2009. In Proceedings of 19th Annual Australasian Society for Biomaterials & Tissue Engineering (ASBTE) Conference (Conference Contribution - Abstract)
  • Waterman, J., Staiger, M.P., Pietak, A., Mahoney, T., Dias, G.J. and Woodfield, T.B.F. (2009) Biomimetic calcium phosphate coatings for improved magnesium metal based orthopaedic implants. Sydney, Australia: 19th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), 21-23 Jan 2009. In Proceedings of the 19th Annual Australasian Society for Biomaterials and Tissue Engineering (ASBTE) Conference (Conference Contribution - Abstract)
  • Walker, J., Kirkland, J., Staiger, M.P., Woodfield, T.B.F. and Dias, G. (2009) HET-CAM: A rapid and inexpensive screening technique for the inflammatory potential of biomaterials. The University of New South Wales, Sydney, Australia: 19th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), 21-23 Jan 2009. In Proceedings of the 19th Annual Australasian Society for Biomaterials & Tissue Engineering (ASBTE) Conference (Conference Contribution - Abstract)
  • Spitters, T., Stroebel, S., Malda, J. and Woodfield, T.B.F. (2009) Perfusion seeding of chondrocytes into 3D-printed polymer scaffolds. The University of New South Wales, Sydney, Australia: 19th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), 21-23 Jan 2009. In Proceedings of 19th Annual Australasian Society for Biomaterials & Tissue Engineering (ASBTE) Conference (Conference Contribution - Abstract)
  • Stroebel, S., Woodfield, T.B.F., Wendt, D., Krause, C. and Martin, I. (2009) Physiological Oxygen Levels Can Enhance The Chondrogenic Redifferentiation Of Human Chondrocytes In 3D Constructs Cultured Under Perfusion. The University of New South Wales, Sydney, Australia: 19th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), 21-23 Jan 2009. In Proceedings of 19th Annual Australasian Society for Biomaterials & Tissue Engineering (ASBTE) Conference (Conference Contribution - Abstract)
  • Kirkland, N.T., Kolbeinsson, I., Woodfield, T., Dias, G. and Staiger, M.P. (2009) Processing-Property Relationships of As-Cast Magnesium Forms With Controllable Architecture. International Journal of Modern Physics B 23(6-7): 1002-1008. http://dx.doi.org/10.1142/S0217979209060373. (Journal Article)
  • Woodfield, T.B.F., Guggenheim, M., von Rechenberg, B., Riesle, J., van Blitterswijk, C.A. and Wedler, V. (2009) Rapid prototyping of anatomically shaped, tissue-engineered implants for restoring congruent articulating surfaces in small joints. Cell Proliferation 42(4): 485-497. http://dx.doi.org/10.1111/j.1365-2184.2009.00608.x. (Journal Article)
  • Nguyen, T., Staiger, M.P., Rabczuk, T., Dias, G. and Woodfield, T.B.F. (2009) Topology optimisation and finite element analysis of ordered porous bone interfacing implants. The University of New South Wales, Sydney, Australia: 19th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), 21-23 Jan 2009. In Proceedings of 19th Annual Australasian Society for Biomaterials & Tissue Engineering (ASBTE) Conference (Conference Contribution - Abstract)
  • Kolbeinsson, I., Staiger, M.P., Dias, G. and Woodfield, T.B.F. (2008) A Novel Processing Route for the Manufacture of Salt Templates With A Controlled Porous Structure. Harbin, China: 5th International Conference on Advanced Materials and Processing (ICAMP-5), 2-5 Sep 2008. (Conference Contribution - Full conference paper)
  • Woodfield, T.B.F., Hooper, G., Vincent, A. and Bell, V. (2008) Evaluation of Knee Joint Proprioception Following Anterior Cruciate Ligament Reconstruction - a 1-year follow-up. Hastings, New Zealand: New Zealand Orthopaedic Association (NZOA) Annual Scientific Meeting 2008, 19-22 Oct 2008. (Conference Contribution - Abstract)
  • Gooch, S.D., Woodfield, T.B.F., Hollingsworth, L., Rothwell, A.G., Medland, A.J. and Yao, F. (2008) On the Design of Manual Wheelchairs for People with Spinal Cord Injuries. Dubrovnik, Croatia: The 10th International Design Conference - DESIGN 2008, 19-22 May 2008. In Proceedings of the DESIGN 2008 387-394. (Conference Contribution - Paper in published proceedings)
  • Kirkland, N.T., Kolbeinsson, I., Woodfield, T., Dias, G. and Staiger, M.P. (2008) Processing-property relationships of as-cast magnesium foams with controllable architecture. Harbin, China: 5th International Conference on Advanced Materials and Processing (ICAMP-5), 2-5 Sep 2008. (Conference Contribution - Full conference paper)
  • Gooch, S., Rothwell, A., Yao, F., Dunn, J. and Woodfield, T. (2007) A Procedure for Measuring Manual Wheelchair Propulsion Ability for People with Spinal Cord Injuries. Shriners Hospitals for Children, Philadelphia, PA, USA: International Meeting on Upper Limb in Tetraplegia Conference, 17-20 Sep 2007. (Conference Contribution - Oral presentation)
  • Gooch, S., Rothwell, A., Yao, F., Dunn, J. and Woodfield, T. (2007) Quantifying Manual Wheelchair Propulsion Ability vs. Injury Level for People with Spinal Cord Injuries. Shriners Hospitals for Children, Philadelphia, PA, USA: International Meeting on Upper Limb in Tetraplegia Conference, 17-20 Sep 2007. (Conference Contribution - Oral presentation)
  • Woodfield, T.B.F., Miot, S., Martin, I., van Blitterswijk, C.A. and Riesle, J. (2006) The regulation of expanded human nasal chondrocyte re-differentiation capacity by substrate composition and gas plasma surface modification. Biomaterials 27(7): 1043-1053. doi:10.1016/j.biomaterials.2005.07.032. (Journal Article)
  • Woodfield, T., Miot, S., Martin, I., van Blitterswijk, C.A. and Riesle, J. (2005) Cell-Based Tissue Engineering Approaches to Repairing Articular Cartilage: Optimised Scaffolds for Optimised Tissues. Christchurch, New Zealand: New Zealand Orthopaedic Assoc (NZOA) Annual Scientific Meeting, 2-5 Oct 2005. http://www.conference.canterbury.ac.nz/ortho/programme.pdf. (Conference Contribution - Oral presentation)
  • Miot, S., Woodfield, T., Daniels, A.U., Suetterlin, R., Peterschmitt, I., Heberer, M., van Blitterswijk, C.A., Riesle, J. and Martin, I. (2005) Effects of Scaffold Composition and Architecture on Human Nasal Chondrocyte Redifferentiation and Cartilagenous Matrix Deposition. Biomaterials 26(15): 2479-2489. doi:10.1016/j.biomaterials.2004.06.048. (Journal Article)
  • Woodfield, T., Malda, J., Miot, S., Martin, I., van Blitterswijk, C.A. and Riesle, J. (2005) Optimized Scaffolds for Optimized Tissues: Scaffold Composition and 3D Architecture Synergistically Enhance Cell Redifferentiation and Tissue Formation. Munich, Germany: SocEuropean Tissue Engineeringiety (ETES) / International Cartilage Repair Society (ICRS) 4th Annual Meeting, 31 Aug-3 Sep 2005. 114. (Conference Contribution - Oral presentation)
  • Woodfield, T.B.F., van Blitterswijk, C.A., de Wijn, J., Sims, T.J., Hollander, A.P. and Riesle, J. (2005) Polymer Scaffolds Fabricated with Pore-Size Gradients as a Model for Studying the Zonal Organization within Tissue-Engineered Cartilage Constructs. Tissue Engineering 11(9-10): 1297-1311. doi: 10.1089/ten.2005.11.1297. (Journal Article)
  • Malda, J., Woodfield, T.B.F., van der Vloot, F., Wilson, C., Martens, D.E., Tramper, J., van Blitterswijk, C.A. and Riesle, J. (2005) The Effect of PEGT/PBT Scaffold Architecture on the Composition of Tissue Engineered Cartilage. Biomaterials 26(1): 63-72. doi:10.1016/j.biomaterials.2004.02.046. (Journal Article)
  • Woodfield, T.B.F. (2004) Cartilage Tissue Engineering: instructing cell-based tissue repair through scaffold design. PhD, University of Twente / IsoTis S.A., Enschede, The Netherlands. (Thesis - Doctor of Philosophy)
  • Woodfield, T.B.F., Malda, J., de Wijn, J., Péters, F., Riesle, J. and van Blitterswijk, C.A. (2004) Design of Porous Scaffolds for Cartilage Tissue Engineering Using a Three-Dimensional Fibre-Deposition Technique. Biomaterials 25(18): 4149-4161. doi:10.1016/j.biomaterials.2003.10.056. (Journal Article)
  • Woodfield, T., Miot, S., Martin, I., van Blitterswijk, C.A. and Riesle, J. (2004) Gas Plasma Treatment and PEGT/PBT Substrate Composition Regulate Human Chondrocyte Adhesion and Re-differentiation Capacity. Sydney, Australia: 7th World Biomaterials Congress, 17-21 May 2004. 1591. (Conference Contribution - Oral presentation)
  • Woodfield, T., Miot, S., van Blitterswijk, C.A., Riesle, J. and Martin, I. (2004) Human Chondrocyte Re-differentiation and Cartilaginous Matrix Deposition are Controlled by 3D Scaffold Composition and Architecture. Sydney, Australia: 7th World Biomaterials Congress, 17-21 May 2004. 1592. (Conference Contribution - Poster presentation)
  • Woodfield, T., de Wijn, J., Sims, T., Hollander, A., van Blitterswijk, C.A. and Riesle, J. (2004) Polymer Scaffolds Fabricated with Organised Pore-size Gradient Structures as a Model for Studying the Zonal Organisation within Tissue Engineered Cartilage Constructs. Sydney, Australia: 7th World Biomaterials Congress, 17-21 May 2004. 1590. http://www.tourhosts.com.au/biomaterials/invit.html. (Conference Contribution - Poster presentation)
  • Malda, J., Woodfield, T.B.F., van der Vloodt, F., Kooya, F.K., Martens, D.E., Tramper, J., van Blitterswijk, C.A. and Riesle, J. (2004) The Effect of PEGT/PBT Scaffold Architecture on Oxygen Gradients in Tissue Engineered Cartilaginous Constructs. Biomaterials 25(26): 5773-5780. doi:10.1016/j.biomaterials.2004.01.028. (Journal Article)
  • Woodfield, T., Wedler, V., Schneller, M., Riesle, J. and van Blitterswijk, C.A. (2004) Towards Customised Tissue Engineered Implants for Reconstruction of Small Articular Joints. Sydney, Australia: 7th World Biomaterials Congress, 17-21 May 2004. 1589. (Conference Contribution - Oral presentation)
  • Woodfield, T., Wedler, V., Schneller, M., van Blitterswijk, C.A. and Riesle, J. (2003) Rapid Prototyped Scaffolds for the Resurfacing of Small Articular Joints. Genova, Italy: European Tissue Engineering Society (ETES) / International Cartilage Repair Society (ICRS) Meeting, 21-23 Sep 2003. (Conference Contribution - Poster presentation)
  • Woodfield, T., Mahmood, T., Riesle, J. and van Blitterswijk, C.A. (2002) Enhanced Cell Attachment and Onset of Chondrogenesis on Glow Discharge Treated 2D and 3D PEGT/PBT Scaffolds. Dallas, TX, USA: 48th Annual Meeting of the Orthopaedic Research Society, 10-13 Feb 2002. (Conference Contribution - Poster presentation)
  • Woodfield, T., Malda, J., de Wijn, J., Riesle, J. and van Blitterswijk, C.A. (2002) Fabrication of PEGT/PBT Scaffolds Containing an Organized Pore-size Gradient Structure. Toronto, Canada: 4th International Cartilage Repair Society (ICRS) Symposium, 15-18 Jun 2002. (Conference Contribution - Poster presentation)
  • Woodfield, T., Malda, J., de Wijn, J., Riesle, J. and van Blitterswijk, C.A. (2002) PEGT/PBT Scaffolds Fabricated with Organized Pore-size Gradient Structures for Cartilage Tissue Engineering Applications. Barcelona, Spain: European Society for Biomaterials (ESB) Conference, 11-14 Sep 2002. (Conference Contribution - Oral presentation)
  • Woodfield, T., Malda, J., de Wijn, J., Riesle, J. and van Blitterswijk, C.A. (2002) Polymer Scaffolds Fabricated with Organized Pore-size Gradient Structures for Cartilage Tissue Engineering. Lunteren, The Netherlands: Nederlandse Vereniging voor Biomaterialen (NVB, Dutch Biomaterials Society) Conference, Dec 2002. (Conference Contribution - Oral presentation)
  • Woodfield, T., Malda, J., de Wijn, J., Riesle, J. and van Blitterswijk, C.A. (2002) Porous PEGT/PBT Scaffolds for Cartilage Tissue Engineering Fabricated Using a 3D-Deposition Technique. Frieburg, Germany: Workshop on Rapid Prototyping for Biomedical Applications, May 2002. (Conference Contribution - Oral presentation)
  • Woodfield, T.B.F., Bezemer, J.M., Pieper, J.S., van Blitterswijk, C.A. and Riesle, J. (2002) Scaffolds for Tissue Engineering of Cartilage. Critical Reviews in Eukaryotic Gene Expression 12(3): 209-236. (Journal Article)
  • Woodfield, T., de Wijn, J., Riesle, J. and van Blitterswijk, C.A. (2001) In Vitro Cartilage Tissue Formation on Porous PEGT/PBT Scaffolds Fabricated Using a 3D-Deposition Technique. Frieburg, Germany: European Tissue Engineering Society (ETES) / International Cartilage Repair Society (ICRS) Meeting, 7-10 Nov 2001. (Conference Contribution - Poster presentation)
  • Woodfield, T., de Wijn, J., Riesle, J. and van Blitterswijk, C.A. (2001) Porous PEGT/PBT Scaffolds for Cartilage Tissue Engineering Fabricated Using a 3D-Deposition Technique – A Preliminary Evaluation. London, UK: European Society for Biomaterials (ESB) Conference, 12-14 Sep 2001. (Conference Contribution - Oral presentation)
  • Woodfield, T., de Wijn, J., Haan, R., Riesle, J. and van Blitterswijk, C.A. (2000) Mechanical Evaluation of Porous PEGT/PBT scaffolds for Tissue Engineering of Articular Cartilage. Lunteren, The Netherlands: Nederlandse Vereniging voor Biomaterialen (NVB, Dutch Biomaterials Society) Conference, Dec 2000. (Conference Contribution - Oral presentation)