UC SPARK - University of Canterbury - New Zealand

Professor Timothy David

Mechanical Engineering; UC High Performance Computing



Phone: +64 3 364 2987 ext. 92094

Office: Civil Mechanical Rm E540

Fields of Research

  • Mathematical and numerical models of cardiovascular blood flow
  • Neurovascular Coupling
  • Computational Physiology
  • Dynamics of Coupled Cells

Researcher Summary

Research interests include:
- Neurovascular coupling
- Dynamics of large vascular trees

Subject Area: Disciplines

Research Groups

Key Methodologies

  • - Massively parallel model of calcium dynamics in arterial structures
  • - Neurovascular coupling

Affiliations

Prizes and Awards

  • Institute of Mathematics and its Applications ( 1997 - 2002)
  • Institute of Physics and Engineering in Medicine ( 1997 - 2002)
  • IPENZ ( 2006 - 2018)

Student Supervision

Displaying all items.
    Current
  • PhD - de Lancea C: 1D models of the Circle of Willis (2016)
  • PhD - Dormanns K: Neurovascular Coupling (2016)
  • PhD - Goodman M: Dynamics of Coupled Cells (2017)
  • PhD - Goodman M: Homogenisation Theory Applied to Coupled Mammalian Cells (2018)
  • PhD - Kenny A: Parallel Simulations of Neurovascular Coupling (2019)
  • PhD - Mathias E: Neurovascular Coupling and the BOLD signal (2016)
  • PhD - PhillipaJohny J: Role of variations in IP3R and RyR in SMC dynamics (2016)
  • PhD - van Ginkel T: Calcium Dynamics in the Neuron (2019)
  • Masters - Dowding S: Coupled Cells in the formation of atheroscerosis (2017)
  • Masters - Kenny A: Calcium Dynamics and Wave Propagation in Coupled Cells (2016)
  • Completed
  • Masters - Shek J: Homogenised models of smooth muscle and endothelial cells (2013)
  • Honours - Mugford J: Coupled cell dynamics (2013)

Research/Scholarly/Creative Works

(Displaying research/scholarly/creative work for last six years)
Chapters
  • David T. and Brown RG. (2013) Models of Cerebrovascular Perfusion. In Becker SMK; Kuznetsov A (Ed.), Transport in Biological Media: 253-273. Oxford: Elsevier.
Journal Articles
  • Kenny A., Zakkaroff C., Plank M. and David T. (2017) Massively parallel simulations of neurovascular coupling with extracellular diffusion. Journal of Computational Science http://dx.doi.org/10.1016/j.jocs.2017.07.001.
  • Zakkaroff C., Moore S., Dowding S. and David T. (2017) 3D time-varying simulations of Ca2+ dynamics in arterial coupled cells: A massively parallel implementation. Communications in Numerical Methods in Engineering 33(2) e02786 http://dx.doi.org/10.1002/cnm.2786.
  • Schluter PJ., Ahuriri-Driscoll A., Anderson TJ., Beere P., Brown J., Dalrymple-Alford J., David T., Davidson A., Gillon DA. and Hirdes J. (2016) Comprehensive clinical assessment of home-based older persons within New Zealand: an epidemiological profile of a national cross-section. Australian and New Zealand Journal of Public Health 40(4): 349-355. http://dx.doi.org/10.1111/1753-6405.12525.
  • de Lancea CL., David T., Alastruey JM. and Brown RG. (2015) Recruitment Pattern in a Complete Cerebral Arterial Circle. Journal of Biomechanical Engineering 137(11) 111004: 11pp. http://dx.doi.org/10.1115/1.4031469.
  • Dormanns K., van Disseldorp EMJ., Brown RG. and David T. (2015) Neurovascular Coupling and the Influence of Luminal Agonists via the Endothelium. Journal of Theoretical Biology 364: 49-70. http://dx.doi.org/10.1016/j.jtbi.2014.08.029.
  • Safaeian N. and David T. (2013) A computational model of oxygen transport in the cerebrocapillary levels for normal and pathologic brain function. Journal of Cerebral Blood Flow and Metabolism 33: 1633-1641. http://dx.doi.org/10.1038/jcbfm.2013.119.
  • Docherty PD., Chase JG. and David T. (2012) Characterisation of the iterative integral parameter identification method. Medical and Biological Engineering and Computing 50(2): 127-134. http://dx.doi.org/10.1007/s11517-011-0851-y.
Conference Contributions - Published
  • Kenny A., Zakkaroff C. and David T. (2016) Massively Parallel Simulations of Neurovascular Coupling. Amsterdam: Virtual Physiological Human, 26-28 Sep 2016. : 395-398.
  • Zakkaroff C., Dowding S., Kenny A. and David T. (2016) Effect of Bifurcation Angles on Arterial Coupled Cell Dynamics: Massively Parallel Simulations. Amsterdam: Virtual Physiological Human, 26-28 Sep 2016. : 240-243.
  • Zakkaroff C., Dowding S., Kenny A. and David T. (2016) In silico simulations of vasodilation. Amsterdam: Virtual Physiological Human, 26-28 Sep 2016. : 195-198.
  • David T., Shaikh MA. and Brown R. (2013) Multiscale Modelling in Physiology: From the Discrete to the Homogenised. Salt Lake City, UT, USA: 11th International Symposium Computer Methods in Biomechanics and Biomedical Engineering, 3-6 Apr 2013. In Proceedings of the 11th International Symposium Computer Methods in Biomechanics and Biomedical Engineering 11: 395-396.
Conference Contributions - Other
  • Goodman M., David T., Docherty PD. and Murray R. (2016) Calcium Dynamics in Coupled Cellular Reaction Diffusion Equations. Queenstown, New Zealand: 34th Australasian Winter Conference on Brain Research, 27-31 Aug 2016
  • Goodman M., David T., Docherty PD. and Murray R. (2016) Homogenisation Theory Applied to Coupled Mammalian Cells. Christchurch, New Zealand: Health Research Society of Canterbury: Christchurch Hospitals' Grand Rounds series 2016, 27-27 May 2016
  • Goodman M., Murray R., Docherty PD. and David T. (2016) Homogenisation Theory with Coupled Cellular Reaction Diffusion Equations. Boston, MA< USA: SIAM Conference on the Life Sciences 2016, 11-14 Jul 2016
  • Kenny A., David T. and Plank M. (2016) Massively parallel simulations of neurovascular coupling with nitric oxide pathway and extracellular diffusion. Queenstown, New Zealand: Massively parallel simulations of neurovascular coupling with nitric oxide pathway and extracellular diffusion, 27-31 Aug 2016
  • van Ginkel T., David T. and Plank M. (2016) Detailed modelling of neuronal calcium dynamics to enable validation of the NVU. Queenstown, New Zealand: Australasian Winter Conference on Brain Research, 27-31 Aug 2016
  • Joel E., Plank M. and David T. (2015) Physiological models of neurovascular coupling and the relationship to BOLD signals in the ageing brain. Queenstown, New Zealand: Australasian Winter Conference on Brain Research, 29 Aug-2 Sep 2015
  • joel E., David T. and Plank M. (2014) Computational modelling of neurovascular coupling pathways with the effects of oxygen dependency of the neuronal membrane. Queenstown: Australasian Winter Conference on Brain Research, 23-27 Aug 2014
  • Johny JP. and David T. (2013) A numerical study into minimal conditions of arterial vasomotion. Thrissur, India: Proceedings of World Congress on Research and Innovations (WCRI 2K13), 1-1 Jul 2013
Additional Publications
  • Kwak D., Ciris K. and David T. (2015) Computational Models of Cerebral Blood Flow under Altered Gravity. In NASA/TM-2015-218825, NASA. Commissioned by NASA.
  • Shaikh SA. and David T. (2012) Massively Parallel Coupled Cell Dynamics for Atherosclerotic regions. Berlin, Germany: http://www.cmbbe2012.cf.ac.uk/.