UC SPARK - University of Canterbury - New Zealand

Dr Constantine Zakkaroff

Department of Accounting and Information Systems

Researcher Summary

Dr Zakkarof is a researcher with experience in cardiovascular image analysis, medical image registration and visualisation. He received his BSc and MSc degrees in computer science from the University of Canterbury, New Zealand, and his PhD from the University of Leeds, United Kingdom. His current research interests are large scale physiological simulation, and high performance computing. Dr Zakkaroff is developing the Coupled Arterial Cells project. At its core, this project has a massively parallel, multi-scale framework for modelling paracrine signalling. The project focuses on the investigation of the relationship between micro-scale cellular dynamics and the resulting emergent macro-scale behaviour as it is exemplified by the growth of atherosclerotic plaques. This approach to the exploration of large-scale emergent behaviour is capable of providing invaluable insights into the onset of coronary heart disease. In silico simulations enable the rapid exploration and pruning of the parameter search space for the refinement and integration of micro-level models into biologically realistic macro-scale models. The in silico simulation provide the opportunity to perform physiological experiments which are impossible in the in vivo or in vitro settings.

Subject Area: Disciplines

Research Groups

Research/Scholarly/Creative Works

  • Zakkaroff C., Biglands JD., Greenwood JP., Plein S., Boyle RD., Radjenovic A. and Magee DR. (2018) Patient-specific coronary blood supply territories for quantitative perfusion analysis. Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization 6(2): 137-154. http://dx.doi.org/10.1080/21681163.2016.1192003. (Journal Articles)
  • Kenny A., Zakkaroff C., Plank M. and David T. (2017) Massively parallel simulations of neurovascular coupling with extracellular diffusion. Journal of Computational Science http://dx.doi.org/10.1016/j.jocs.2017.07.001. (Journal Articles)
  • Zakkaroff C., Moore S., Dowding S. and David T. (2017) 3D time-varying simulations of Ca2+ dynamics in arterial coupled cells: A massively parallel implementation. Communications in Numerical Methods in Engineering 33(2) e02786 http://dx.doi.org/10.1002/cnm.2786. (Journal Articles)
  • Dowding S., Zakkaroff C. and Johny JP. (2016) In Silico Simulations of In Vitro Vasodilation Experiments. Amsterdam: Virtual Physiological Human, 26-28 Sep 2016. : 195-198. (Conference Contributions - Published)
  • Kenny A., Zakkaroff C. and David T. (2016) Massively Parallel Simulations of Neurovascular Coupling. Amsterdam: Virtual Physiological Human, 26-28 Sep 2016. : 395-398. (Conference Contributions - Published)
  • Zakkaroff C., Biglands JD., Greenwood JP., Plein S., Boyle RD., Radjenovic A. and Magee DR. (2016) Investigation into diagnostic accuracy of common strategies for automated perfusion motion correction. Journal of Medical Imaging 3(2) http://dx.doi.org/10.1117/1.JMI.3.2.024002. (Journal Articles)
  • Zakkaroff C., Dowding S., Kenny A. and David T. (2016) Effect of Bifurcation Angles on Arterial Coupled Cell Dynamics: Massively Parallel Simulations. Amsterdam: Virtual Physiological Human, 26-28 Sep 2016. : 240-243. (Conference Contributions - Published)
  • Zakkaroff C. and David T. (2015) Bifurcating Blood Vessel Quad Mesh Generation for Large-Scale Parallel Simulations. Queenstown, New Zealand: eResearch NZ 2015, 23-25 Mar 2015. (Conference Contributions - Published)
  • Zakkaroff C., Radjenovic A., Biglands JD., Plein S., Greenwood JP. and Magee DR. (2014) A Comparison of Methods for Automated Motion Correction of DCE-MRI Perfusion Datasets Evaluated in Terms of Diagnostic Accuracy: A CE-MARC sub-study. (Conference Contributions - Published)
  • Zakkaroff C., Radjenovic A., Biglands JD., Plein S., Greenwood JP. and Magee DR. (2014) A comparison of methods for automated motion correction of DCE-MRI perfusion datasets evaluated in terms of diagnostic accuracy: a CE-MARC sub-study. In Journal of Cardiovascular Magnetic Resonance 16(Suppl 1) P206: P206-P206. http://dx.doi.org/10.1186/1532-429X-16-S1-P206. (Conference Contributions - Published)
  • Zakkaroff C., Radjenovic A., Biglands JD., Plein S., Greenwood JP. and Magee DR. (2014) Automated registration of dynamic contrast enhanced DCE-MRI cardiac perfusion achieves comparable diagnostic accuracy to manual motion correction: a CE-MARC sub-study. New Orleans, LA, USA: 17th Annual Society for Cardiovascular Magnetic Resonance Scientific Sessions, 16-19 Jan 2014. In Journal of Cardiovascular Magnetic Resonance 16(Suppl 1) P344 http://dx.doi.org/10.1186/1532-429X-16-S1-P344. (Conference Contributions - Published)
  • Zakkaroff C., Radjenovic A., Biglands JD., Plein S., Greenwood JP. and Magee DR. (2014) Registration of Coronary MRA to DCE-MRI Myocardial Perfusion Series Improves Diagnostic Accuracy Through the Computation of Patient-Specific Coronary Supply Territories: A CE-MARC Sub-Study. Journal of Cardiovascular Magnetic Resonance (Journal Articles)
  • Zakkaroff C. (2013) Fusion of magnetic resonance coronary angiography and dynamic contrast-enhanced magnetic resonance cardiac perfusion series for patient-specific perfusion analysis and visualisation / by Constantine Zakkaroff. Leeds, UK. University of Leeds. (Theses / Dissertations)
  • Zakkaroff C., Radjenovic A., Greenwood JP. and Magee D. (2012) Recovery of Slice Rotations with the Stack Alignment Transform in Cardiac MR Series. Surrey, UK: British Machine Vision Conference, 3-7 Sep 2012. (Conference Contributions - Published)
  • Zakkaroff C., Radjenovic A., Greenwood JP. and Magee D. (2012) Stack Alignment Transform for Misalignment Correction in Cardiac MR Cine Series. Swansea, UK: Medical Image Understanding and Analysis, 9-11 Jul 2012. (Conference Contributions - Published)
  • Zakkaroff C., Magee D., Radjenovic A. and Boyle R. (2010) Mediated Spatiotemporal Fusion of Multiple Cardiac Magnetic Resonance Datasets for Patient-specific Perfusion Analysis. Belfast, UK: Computing in Cardiology, 26-29 Sep 2010. (Conference Contributions - Published)
  • Zakkaroff C., Magee D., Radjenovic A. and Boyle R. (2010) Mediated Spatiotemporal Registration of Cardiac DCE-MRI and Coronary MR Angiography. Beijing, China: Spatio-Temporal Image Analysis for Longitudinal and Time-Series Image Data workshop held in conjunction with Medical Image Computing and Computer-Assisted Interventions, 20-24 Sep 2010 (Conference Contributions - Other)
  • Mitrovic A., Martin B., Suraweera P., Zakharov K., Milik N., Holland J. and McGuigan N. (2009) ASPIRE: An Authoring System and Deployment Environment for Constraint-Based Tutors. International Journal of Artificial Intelligence in Education 19(2): 155-188. http://iaied.org/pub/1150/. (Journal Articles)
  • Suraweera P., Mitrovic A., Martin B., Holland J., Milik N., Zakharov K. and McGuigan N. (2009) Using Ontologies to Author Constraint-Based Intelligent Tutoring Systems. In Dicheva D; Mizoguchi R; Greer J (Ed.), Semantic Web Technologies for E-Learning: 77-95. Amsterdam: IOS Press. (Chapters)
  • Zakharov K., Mitrovic A. and Johnston L. (2008) Towards Emotionally-Intelligent Pedagogical Agents. Montreal, Canada: 9th International Conference on Intelligent Tutoring Systems, 23-27 Jun 2008. In Lecture Notes in Computer Science (LNCS) 5091,: 19-28. http://dx.doi.org/10.1007/978-3-540-69132-7_7. (Conference Contributions - Published)
  • Zakharov K., Mitrovic A. and Johnston L. (2007) Pedagogical Agents Trying on a Caring Mentor Role. Los Angeles, CA, USA: 13th International Conference on Artificial Intelligence in Education (AIED 2007), 9-13 Jul 2007. In Frontiers in Artifical Intelligence and Applications 158: 59-66. http://www.isi.edu/AIED2007/. (Conference Contributions - Published)
  • Mitrovic A., Suraweera P., Martin B., Zakharov K., Milik N. and Holland J. (2006) Authoring Constraint-Based Tutors in ASPIRE. Jhongli, Taiwan: 8th International Conference on Intelligent Tutoring Systems, 26-30 Jun 2006. In Lecture Notes in Computer Science (LNCS) 4053(Intelligent Tutoring Systems): 41-50. http://dx.doi.org/10.1007/11774303_5. (Conference Contributions - Published)
  • Zakharov K., Mitrovic A. and Ohlsson S. (2005) Feedback Micro-engineering in EER-Tutor. Amsterdam, Netherlands: 12th International Conference on Artificial Intelligence in Education (AIED 2005), 18 Jul 2005. : 718-725. http://hcs.science.uva.nl/AIED2005/. (Conference Contributions - Published)