Qualifications & Memberships
Research in our lab focuses on the structure, function and inhibition of key enzymes involved in infection and disease. We are also interested in the evolution of enzyme function, and conversely its design and manipulation.We study a variety of enzymes: from those responsible for the biosynthesis of amino acids, in particular lysine, since these are validated drug targets; to glycolytic enzymes, such as pyruvate kinase, since these are tractable model systems to understand enzyme allostery. The list is ever increasing.A common theme in the lab is the role protein-protein interactions in a variety of biological systems, mostly derived from bacteria, but more recently including eukaryotic proteins involved in cancer, where we hope to address the twin problems of how and why proteins form complexes and the functional consequences of these associations.
- Peng F., Widmann S., Wünsche A., Duan K., Donovan KA., Dobson RCJ., Lenski RE. and Cooper TF. (2018) Effects of Beneficial Mutations in pykF Gene Vary over Time and across Replicate Populations in a Long-Term Experiment with Bacteria. Molecular Biology and Evolution 35(1): 202-210. http://dx.doi.org/10.1093/molbev/msx279.
- Kavianinia I., Yang S-H., Kaur H., Harris PWR., Dobson RCJ., Fairbanks AJ. and Brimble MA. (2017) Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides.. Chemical Communications http://dx.doi.org/10.1039/c7cc05025a.
- North RA., Horne CR., Davies JS., Remus DM., Muscroft-Taylor AC., Goyal P., Wahlgren WY., Ramaswamy S., Friemann R. and Dobson RCJ. (2017) "Just a spoonful of sugar...": import of sialic acid across bacterial cell membranes.. Biophysical Reviews http://dx.doi.org/10.1007/s12551-017-0343-x.
- Pearce FG., Hudson AO., Loomes K. and Dobson RCJ. (2017) Dihydrodipicolinate synthase: Structure, dynamics, function, and evolution. 83: 271-289. http://dx.doi.org/10.1007/978-3-319-46503-6_10.
- Rogov VV., Stolz A., Ravichandran AC., Rios-Szwed DO., Suzuki H., Kniss A., Löhr F., Wakatsuki S., Dötsch V. and Dikic I. (2017) Structural and functional analysis of the GABARAP interaction motif (GIM). EMBO Reports 18(8): 1382-1396. http://dx.doi.org/10.15252/embr.201643587.