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Jim Coxon

Rutherford 640
Internal Phone: 6872

Qualifications & Memberships

Research Interests

My research interest is in understanding organic reactions, particularly those of value in synthesis and or biochemistry. Many of our studies have involved the timing of molecular events and the difference in energy of competing processes including: strained small ring opening and molecular rearrangement, factors responsible for facial selection in cycloaddition reactions and - reactions at carbonyls, and the use of chiral templates in inducing selection. Other interests include molecular modelling studies (ab initio studies of strained ring rearrangements, carbohydrate solution properties, macrocyclic conformational problems and protein structure) and Cataract research (a joint project with Professor Andrew Abell and colleagues at Lincoln focuses in development of calpain inhibitors).

Recent Publications

  • Coxon JM. (2015) Molecular Rearrangements. Organic Reaction Mechanisms, 2012: An annual survey covering the literature dated January to December 2012: 469-540. http://dx.doi.org/10.1002/9781118930786.ch12.
  • Jiao W., M DQ., Coxon JM. and Parker EJ. (2010) Molecular modeling studies of peptide inhibitors highlight the importance of conformational prearrangement for inhibition of calpain. Biochemistry 49(26): 5533-5539. http://dx.doi.org/10.1021/bi100048y.
  • Abell AD., Alexander NA., Aitken SG., Chen H., Coxon JM., Jones MA., McNabb SB. and Muscroft-Taylor A. (2009) Synthesis of macrocyclic β-strand templates by ring closing metathesis. Journal of Organic Chemistry 74(11): 4354-4356. http://dx.doi.org/10.1021/jo802723w.
  • Abell AD., Jones MA., Coxon JM., Morton JD., Aitken SG., McNabb SB., Lee HYY., Mehrtens JM., Alexander NA. and Stuart BG. (2009) Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors. Angewandte Chemie 48(8): 1455-1458. http://dx.doi.org/10.1002/anie.200805014.
  • Jones MA., Coxon JM., McNabb SB., Mehrtens JM., Alexander NA., Jones S., Chen H., Buisan C. and Abell AD. (2009) Efficient large-scale synthesis of CAT811, a potent calpain inhibitor of interest in the treatment of cataracts. Australian Journal of Chemistry 62(7): 671-675. http://dx.doi.org/10.1071/CH09101.