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Bioreactor design and operation including bacteria, yeast and tissue culture, formulation, bioseparations.
TopicsDr. Gabriel Visnovsky (Teaching weeks 1-4 and 11-12): 18 lecturesAnimal cell culture: uses and applications in industry and biotechnology • Introduction and history. • Design and requirements for setting up an animal cell culture lab. • Security in the lab. • Animal cell culture characteristics and requirements. • Quality control • General techniques and systems for cultivation of animal cells: static, suspension and microcarriers cell culture.• Factors influencing cell growth: shear stress, bioreactor design and process scale up • Strategies for production process design. Lab, pilot, and large scale: CSTR vs. ALR • Case Study I: Production of Baculovirus in large scale airlift reactors using insect cells• Case Study II: Development, optimisation and scale up of a biotechnological process to produce Oryctes virus.Prof. Conan Fee (Teaching weeks 5-10): 18 lectures (Room E528 ext 94078)Bioseparations and Chromatography • Bioproducts• Review of biological molecule properties (emphasis on proteins)• General bioseparation principles• Process scale protein chromatography• Adsorption isotherms• Bioseparation strategies• Optimisation and scale-up
ENGR407
Gabriel Visnovsky
Ratledge, Colin. , Kristiansen, B; Basic biotechnology ; 3rd ed; Cambridge University Press, 2006.
Domestic fee $1,038.00
International fee $5,000.00
* All fees are inclusive of NZ GST or any equivalent overseas tax, and do not include any programme level discount or additional course-related expenses.
For further information see Chemical and Process Engineering .