BCHM403-13W (C) Whole Year 2013
Protein Science

Description

In this course we will take an in depth look at the structure and function of proteins, with an emphasis on how understanding the fundamental biochemistry of proteins opens up exciting areas of research.

Proteins play an essential role in life, acting as catalysts to speed up chemical reactions, scaffolds that determine cell shape, or signalling molecules that regulate development and responses.

Initial sessions will look at mastering contemporary protein science issues, using a range of proteins to illustrate issues in protein science. We will explore the methodology used in studying enzymes and the data that is obtained. The aim is to build a sound understanding of contemporary protein science and an ability to think critically about the current research literature in the field. We will cover a range of issues including protein purification and characterization; protein folding and aggregation; and the structure, function and evolution of biosynthetic enzymes.

The main part of the course involves a series of case studies that will build on the fundamental material. Using your knowledge of protein science, you will choose a project to show your understanding of the scientific method and how it relates to proteins. The case studies will come from widely different fields, but will all rely on a fundamental understanding of scientific method and protein science. Examples will depend on specific interests of the participants and may include: medical applications, such as approaches to combat cancer, diabetes and Alzheimer's disease; protein folding and misfolding; agricultural applications, such as "herbicide design"; food applications, such as the use of enzymes (in place of chemicals) to improve food processing; and biotechnological applications, such as the immobilised enzymes and cells for the efficient production of useful compounds.

Learning Outcomes

• A detailed understanding of some of the techniques used in protein science

• An appreciation of why protein science is important in research

• An understanding of the scientific practice and principles of protein science

• The ability to access and utilize the scientific literature

• The ability to analyse and critically interpret experimental data and published research

• Well developed skills in the verbal and written presentation of scientific ideas

Pre-requisites

Restrictions

Equivalent Courses

For further information see School of Biological Sciences.