Research interests and activities include modelling and control of the glucose regulatory system in intensive care. This research develops methodologies to identify patient metabolic state in both adults and prematurely born infants. Forecasting techniques are developed to predict evolution of metabolism for control. Simulation studies are used to optimise control strategies to adapt to local clinical practices. Pilot clinical trials are conducted to verify simulation outputs and prepare glucose control systems for wider adoption into typical clinical usage.
Other research interests include assessing sensitivity to insulin as a marker of patient illness, modelling the cardiovascular and renal systems, and investigating the wider cost and health benefits of improved glucose control for critically ill patients.