UC Spark

Associate Professor Frank Sin

Biological Sciences

Fields of Research

  • DNA fingerprinting
  • Ecogenetics
  • Ecological monitoring by genetic techniques
  • Forensic gene typing
  • Genetic screening
  • Genetics of human ageing
  • Genetics of human male infertility
  • Genotyping of live stock
  • Mitochondrial gene analysis
  • Mutation analysis

Researcher Summary

Research interests include molecular genetics of ageing, genetic engineering, mutation analysis, and the genetics human fertility. Specific interests are:
- Genetics of human male infertility
- Mitochondrial mutations on cell growth
- Mitochondrial ageing
- Molecular marine biology and biotechnology

Subject Area: Disciplines

Future Research

  • Private consultancy after retirement

Key Methodologies

  • Biochemical analysis
  • Cell culture
  • Gene structural analysis
  • Polymerase chain reaction for genetic screening and forensic investiagation

Affiliations

Publications


  • Bryant, M.J., Flint, H.J. and Sin, F.Y.T. (2006) Isolation, Characterization, and Expression Analysis of Three Actin Genes in the New Zealand Black-Footed Abalone, Haliotis iris. Marine Biotechnology 8(2): 110-119. http://dx.doi.org/10.1007/s10126-005-5139-5. (Journal Article)
  • Harris, T.P., Gomas, K.P., Weir, F., Holyoake, A.J., McHugh, P., Wu, M., Sin, Y. and Sin, F.Y.T. (2006) Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men. International Journal of Andrology 29(3): 421-433. http://dx.doi.org/10.1111/j.1365-2605.2005.00633.x. (Journal Article)
  • Richardson, S.J., Monk, J.A., Shepherdley, C.A., Ebbesson, L.O.E., Sin, F., Power, D.M., Frappell, P.B., Köhrle, J. and Renfree, M.B. (2005) Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 288: R1264-R1272. (Journal Article)
  • Sin, F.Y.T., Harris, T., Gomas, K., Weir, F. and Sin, I.L. (2005) Relationship between DNA polymerase gamma genotypes and mitochondrial mutation in fertile and subfertile men. Seoul, Korea: Eighth International Congress of Andrology, 12-16 Jun 2005.(S-C. Kim, J.A. Grootegoed and H.E. Cheme (ed.)) 37-43. (Conference Contribution - Full conference paper)
  • Gemmell, N.J. and Sin, F.Y.T. (2002) Mitochondrial mutations may drive Y chromosome evolution. BioEssays 24(3): 275-279. doi:10.1002/bies.10062. (Journal Article)
  • Gomas, K.P., Sin, I.L. and Sin, F.Y. (2002) The association of single nucleotide substitutions in the mitochondrial ND1 and ND2 genes with poor semen parameters in man.. Sydney, Australia: Genetics Society of Australia, 9-12 July 2002. 49. (Conference Contribution - Other)
  • Holyoake, A.J., McHugh, P., Wu, M., O'Carrol, S., Benny, P., Sin, I.L. and Sin, F.Y.T. (2001) High incidence of single nucleotide substitutions in the mitochondrial genome is associated with poor semen parameters in men. International Journal of Andrology 24: 175-182. (Journal Article)
  • Khoo, J.G.I. and Sin, F.Y.T. (2001) Molecular cloning and characterisation of a novel membrane receptor gene from the lobster Jasus edwardsii. : 3369-3377. (Journal Article)
  • Sin, F.Y.T., Walker, S.P., Symonds, J.E., Mukherjee, U.K., Khoo, J.G.I. and Sin, I.L. (2000) Electroporation of salmon sperm for gene transfer: efficiency, reliability, and fate of transgene. Mol. Repro. & Develop. 56: 285--8. (Journal Article)
  • Kerr, Natalie J., Zhang, Jin., Frank, Y.T., Benny, Peter. and Sin, Iris L. (2000) Frequency of microdeletions in the azoospermia factor region of the Y-chromosome of New Zealand men. The New Zealand Medical Journal 113(1121): 460--2. (Journal Article)
  • Holyoake, A.J., Sin, I.L., Benny, P.S. and Sin, F.Y.T. (1999) Association of a novel human mtDNA ATPase6 mutation with immature sperm cells. Andrologia 31: 339--45. (Journal Article)
  • Khoo, Jenny G.I. and Sin, Frank Y.T. (1999) Isolation and characterization of a novel peptide gene in the lobster Jasus edwardsii. Zoological Studies 38(1): 95--109. (Journal Article)
  • Sin, Frank Y.T. (1998) Sperm-DNA interaction. Trends in Comparative Biochem. & Physiol. 5: 229--35. (Journal Article)
  • Sin, F.Y.T., Mukherjee, U.K., Walker, L. and Sin, I.L. (1997) The application of gene transfer techniques to marine resource management: recent advances, problems and future directions. Hydrobiologia 352: 263--78. (Journal Article)
  • Sin, F.Y.T. (1997) Transgenic fish. Reviews in Fish Biology and Fisheries 7: 417--41. (Journal Article)